Unokukhulelwa njani ngokukhawuleza kwi-metformin? .
Iingcali zeGynecologists zisebenzisa i-metformin njengenxalenye yonyango lokukhulelwa; sixelela indlela:
IMetformin ukukhulelwa
Abafazi abane Ukunganyangeki kwi-insulin zinokuba ezahlukeneyo iingxaki zamanina , kubandakanya ubunzima bokukhulelwa. Ke ngoko, iigynecologists zicamngca nge-metformin ukunceda owasetyhini ukuba alawule ukunganyangeki kwe-insulin kwaye agcine umjikelo owaneleyo wokuya exesheni kunye nokufezekisa ukukhulelwa.
I-Metformin ayinjalo njengonyango lokuzala , kodwa yona Unceda ukulawula umjikelo wokuya exesheni kwabasetyhini abachaphazelekayo Ukunganyangeki kwi-insulin kwaye ke ukufezekisa ukukhulelwa ngokulula . Kwakhona, ukuba owasetyhini ulawula ukumelana ne-insulin, akazukukhulelwa kuphela kodwa uya kuwunciphisa kakhulu umngcipheko wokuphulukana nosana kwezi nyanga zilandelayo zokukhulelwa.
Xa owasetyhini ekwazi ukulinganisa imeko yakhe yehomoni, ibonisa uGqirha wangaphakathi uJosé Víctor Manuel Rincón Ponce, weZiko loKhuseleko loLuntu laseMexico, imijikelo yakhe yokuya exesheni nayo iyenziwa rhoqo, kwaye ke kuya kubalula ukuvelisa imeko efanelekileyo yomzimba wakhe kunye nokugcina ixesha elipheleleyo lokukhulelwa.
Ukufumana ubunzima bokukhulelwa kwi-polycystic ovary syndrome
Isifo sePolycystic ovary syndrome, isifo esibonakaliswa kukungabikho mgaqweni, uguquko kwihomoni, kunye nokubonakala kwee-cysts ezininzi kwii-ovari, ichaphazela malunga ne-8% yabasetyhini. Yintoni ebangela esi sifo asithandabuzeki, kwaye ukuxilongwa kunye nonyango kuxoxiwe kakhulu.
Into eyaziwayo kukuba esi sesinye sezizathu eziphambili zokungachumi kwabasetyhini, apho unokongeza khona iingxaki ezithile zokutya, njengokutyeba kakhulu okanye ukunganyangeki kwe-insulin.
Isifundo esenziwe liqela labaphandi abavela kwiiyunivesithi ezahlukeneyo zaseMelika, ukuze kuqinisekiswe iziphumo zezifundo ezincinci kwi Eyona ndlela yokunyanga ukungachumi kubafazi abane-polycystic ovarian syndrome , kwaye epapashwe kwiThe New magazine iNgilane Journal of Medicine, ichaza ukuba amayeza amadala asetyenziselwa ukwenza i-ovulation ngokusebenzisa isenzo sayo kwi-follicle-evuselela i-hormone, I-clomiphene citrate, yeyona ndlela ilungileyo kwabasetyhini abanengxaki yokukhulelwa , ikwayindlela elula, engabizi mali ininzi, ekhuselekileyo nesebenzayo.
Ukusetyenziswa kutshanje kwakuyi-metformin, iyeza elisetyenziselwa ukunyanga isifo seswekile sesi-2, esathi ngokuphucula iswekile kunye nokukhuluphala. Olu phononongo lwenziwa kunye nabasetyhini abangama-626 abangazalanga ngenxa yesi sifo kwaye basasaza ngokwamaqela amathathu, elinye iqela lafumana ichiza elichasene nesifo seswekile (i-metformin ekhutshiweyo eyandisiweyo), enye inducer ye-ovulation (i-clomiphene citrate) kwaye owesithathu wafumana indibaniselwano yomibini amayeza . Unyango kunye nokulandelelana kuye kwahlala ubuninzi beeveki ezingama-30 okanye de bakufumana ukukhulelwa.
Ekupheleni kophononongo, abasetyhini abafumene i-clomiphene babonisa inqanaba lokuzalwa eliphindwe kathathu kunelo leqela le-metformin; Ukongeza, eyangaphambili ikwanenani eliphezulu lokukhulelwa okuninzi.
Abo bathathe indibaniselwano yamachiza omabini babonisa inqanaba le-ovulation eliphezulu kunamanye, kodwa ukuzalwa akuzange kuzalisekiswe, nangona befanisa ukukhulelwa okuninzi neqela elafumana i-ovulation inducer.
Izifundo zangaphambili beziphakamise okwahlukileyo koku, kodwa isiphumo asihlalutywanga ekuzalweni, kodwa kwinqanaba le-ovulation, elingenguye umnqweno wabasetyhini abanesi sifo.
Izalathiso:
Ijenali yokujonga Iinkcukacha ezithe xaxe
- IBarbieri RL, et al. (2017). I-Metformin kunyango lwe-polycystic ovary syndrome.
uptodate.com/contents/metformin-for-treatment-of-the-polycystic-ovary-syndrome - Zibophelele kukhetho olusempilweni ukunceda ukuthintela iziphene zokuzalwa. (2017).
cdc.gov/ncbddd/birthdefects/prevention.html - I-Feig DS, okqhubekayo. (2011). Unyango lweMetformin ngexesha lokukhulelwa. INGXELO:
doi.org/10.2337/dc11-1153 - Iipilisi zeGlucophage (metformin hydrochloride); I-Glucophage XR (metformin hydrochloride) iipilisi zokukhupha ezandisiweyo. (2017).
accessdata.fda.gov/drugsatfda_docs/label/2017/020357s037s039,021202s021s023lbl.pdf - Abasebenzi bekliniki yaseMayo. (2017). Isifo seswekile.
mayoclinic.org/diseases-conditions/gestational-diabetes/basics/risk-factors/con-20014854
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